Machado | Ehmsg2019

Jose Carlos L. MACHADO

Pubmed Publications List

Birthday: 14th July, 1969
Nationality: Portuguese
Address:

Institute for Research and Innovation in Health – i3S

Rua Alfredo Allen 208

4200-135 Porto, Portugal

phone 351 225570796

E-mail josem@ipatimup.pt

Academic qualifications

1992 Graduate degree in Biology by the Faculty of Sciences of the University of Porto.
1994 M.Sc. degree in Oncobiology by the Faculty of Medicine of the University of Porto.
1999 Ph.D. degree in Human Biology by the Faculty of Medicine of the University of Porto.
2020 Habilitation in Biomedicine by the Faculty of Sciences of the University of Porto.

Postgraduate Training

1990 – 1991 Instructor in Zoology, Faculty of Sciences, University of Porto, Portugal.

1994 – 1997 PhD student, Institute of Anthropology and Human Genetics, University of Tübingen, Germany.

1997 – 1999 PhD student, IPATIMUP-Institute of Molecular Pathology and Immunology of the University of Porto, Portugal.

1999 – 2000 Postdoctoral Fellow, Department of Molecular Biology, University of Ghent-VIB, Belgium.

2000 – 2001 Postdoctoral Fellow, IPATIMUP-Institute of Molecular Pathology and Immunology of the University of Porto, Portugal.

Academic Appointments

2001 – 2007 Assistant Professor, Medical Faculty of Porto, Portugal.

2001 – 2014 Principal Investigador, IPATIMUP-Institute of Molecular Pathology and Immunology of the University of Porto, Portugal.

2007 – present Associate Professor, Medical Faculty of Porto, Portugal.

2013 – present Vice-President of the Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP).

2015 – present Principal Investigator at the Institute for Research and Innovation in Health (i3S).

2018 – present Board of Directors member of the the Institute for Research and Innovation in Health (i3S).

2019 – present Coordinator of the Cancer Programme at the Institute for Research and Innovation in Health (i3S).

Awards

1991 – 1992 Research Fellowship from Portuguese Scientific Research Board (JNICT).

1992 – 1994 M.Sc. Fellowship from Portuguese Scientific Research Board (JNICT).

1994 – 1999 Ph.D. Fellowship from Foundation for Science and Technology, Portuguese Ministry of Science and Technology.

1999 – 2001 Post-doctoral Fellowship from Foundation for Science and Technology, Portuguese Ministry of Science and Technology.

2000 Young Researcher Prize from the European Cancer Prevention Organization (ECP).

2001 Scholar-in-training Award for Promising Cancer Research from the American Association for Cancer Research (AACR).

2002 Portuguese Society of Human Genetics Award

2004 Portuguese Society of Gastroenterology Award

2005 Portuguese Society of Gastroenterology Award

2018 PFIZER 2018 Prize for Clinical Investigation.

Research Interest

The scientific question that drives my research is how mutations that arise in cancer cells spread among cell subpopulations and, in the process, help shape its plasticity and the tumor microenvironment. I want to understand how cancer cells communicate with each other and with other cells, and how does it influence, and is influenced, by clinical events such as therapy and disease progression. H. pylori-related gastric carcinoma is one of the central models of research we use.

Publications

10 Selected publications in the field of Cancer Research

1. Machado JC, Oliveira C, Carvalho R, Soares P, Berx G, Caldas C, Seruca R, Carneiro F, Sobrinho-Simões M. E-cadherin gene (CDH1) promoter methylation as the second hit in sporadic diffuse gastric carcinoma. Oncogene 20: 1525-1528, 2001.

2. Machado JC, Pharoah P, Sousa S, Carvalho R, Oliveira C, Figueiredo C, Amorim A, Seruca R, Caldas C, Carneiro F, Sobrinho-Simões M.

Interleukin1? and interleukin 1RN polymorphisms are associated with increased risk of gastric carcinoma. Gastroenterology 121: 823-829,

2001.

3. Figueiredo C, Machado JC, Pharoah P, Seruca R, Sousa S, Carvalho R, Capelinha AF, Quint W, Caldas C, van Doorn LJ, Carneiro F, Sobrinho-

Simões M. Helicobacter pylori and interleukin-1 genotyping: An opportunity to identify high-risk individuals for gastric carcinoma. J Natl Cancer

Inst 94: 1680-1687, 2002.

4. Machado JC, Figueiredo C, Canedo P, Pharoah P, Carvalho R, Nabais S, Alves CC, Campos ML, van Doorn LJ, Caldas C, Seruca R, Carneiro F,

Sobrinho-Simões M. A pro-inflammatory genetic profile increases the risk of chronic atrophic gastritis and gastric carcinoma. Gastroenterology

125: 364-371, 2003.

5. Resende C, Regalo G, Durães C, Carneiro F, Machado JC. Genetic changes of CEBPA in cancer. Mutations or polymorphisms? J Clin Oncol 25:

2493-2494, 2007.

6. Canedo P, Corso G, Pereira F, Lunet N, Suriano G, Figueiredo C, Pedrazzani C, Moreira H, Barros H, Carneiro F, Seruca R, Roviello F, Machado JC.

The interferon gamma receptor 1 (IFNGR1) -56C/T gene polymorphism is associated with increased risk of early gastric carcinoma. Gut

57:1504-1508, 2008.

7. Ferreira AC, Suriano G, Mendes N, Gomes B, Wen X, Carneiro F, Seruca R, Machado JC. E-cadherin impairment increases cell survival through

Notch-dependent upregulation of Bcl-2 activation. Hum Mol Genet 21:334-343, 2012.

8. Costa JL, Sousa S, Justino A, Kay T, Fernandes S, Cirnes L, Schmitt F, Machado JC. Non Optical Massive Parallel DNA Sequencing of BRCA1 and

BRCA2 Genes in a Diagnostic Setting. Hum Mutat 34:629-35, 2013.

9. Malfertheiner P, Megraud F, O'Morain CA, Gisbert JP, Kuipers EJ, Axon AT, Bazzoli F, Gasbarrini A, Atherton J, Graham DY, Hunt R, Moayyedi P,

Rokkas T, Rugge M, Selgrad M, Suerbaum S, Sugano K, El-Omar EM, European Helicobacter and Microbiota Study Group and Consensus panel.

Management of Helicobacter pylori infection-the Maastricht V/Florence Consensus Report. Gut 66:6-30, 2017.

10. Ferreira RM, Pereira-Marques J, Pinto-Ribeiro I, Costa JL, Carneiro F, Machado JC, Figueiredo C. Gastric microbial community profiling reveals a

dysbiotic cancer-associated microbiota. Gut 2018 67:226-236, 2018.

Number of Publications

165

H index

10 best publications on Helicobacter

1. Machado JC, Pharoah P, Sousa S, Carvalho R, Oliveira C, Figueiredo C, Amorim A, Seruca R, Caldas C, Carneiro F, Sobrinho-Simões M. Interleukin

1? and interleukin 1RN polymorphisms are associated with increased risk of gastric carcinoma. Gastroenterology 121: 823-829, 2001.

2. Figueiredo C, Machado JC, Pharoah P, Seruca R, Sousa S, Carvalho R, Capelinha AF, Quint W, Caldas C, van Doorn LJ, Carneiro F, Sobrinho-

Simões M. Helicobacter pylori and interleukin-1 genotyping: An opportunity to identify high-risk individuals for gastric carcinoma. J Natl Cancer

Inst 94: 1680-1687, 2002.

3. Machado JC, Figueiredo C, Canedo P, Pharoah P, Carvalho R, Nabais S, Alves CC, Campos ML, van Doorn LJ, Caldas C, Seruca R, Carneiro F,

Sobrinho-Simões M. A pro-inflammatory genetic profile increases the risk of chronic atrophic gastritis and gastric carcinoma. Gastroenterology

125: 364-371, 2003.

4. Canedo P, Corso G, Pereira F, Lunet N, Suriano G, Figueiredo C, Pedrazzani C, Moreira H, Barros H, Carneiro F, Seruca R, Roviello F, Machado JC.

The interferon gamma receptor 1 (IFNGR1) -56C/T gene polymorphism is associated with increased risk of early gastric carcinoma. Gut

57:1504-1508, 2008.

5. Malfertheiner P, Megraud F, O’Morain CA, Atherton J, Axon ATR, Bazzoli F, Gensini GF, Gisbert JP, Graham DY, Rokkas T, El-Omar EM, Kuipers EJ,

The European Helicobacter Study Group (EHSG). Management of Helicobacter pylori infection – the Maastricht IV/ Florence Consensus Report.

Gut 61:646-664, 2012.

6. Ferreira RM, Machado JC, Letley D, Atherton JC, Pardo ML, Gonzalez CA, Carneiro F, Figueiredo C. A novel method for genotyping Helicobacter

pylori vacA intermediate region directly in gastric biopsy specimens. J Clin Microbiol 50:3983-3989, 2012.

7. Correia M, Casal S, Vinagre J, Seruca R, Figueiredo C, Touati E, Machado JC. Helicobacter pylori’s cholesterol uptake impacts resistance to

docosahexaenoic acid. Int J Med Microbiol 304:314-20, 2014.

8. Resende C, Regalo G, Durães C, Pinto MT, Wen X, Figueiredo C, Carneiro F, Machado JC. Interleukin-1B signalling leads to increased survival of

gastric carcinoma cells through a CREB-C/EBPβ-associated mechanism. Gastric Cancer 19:74-84, 2016.

9. Malfertheiner P, Megraud F, O'Morain CA, Gisbert JP, Kuipers EJ, Axon AT, Bazzoli F, Gasbarrini A, Atherton J, Graham DY, Hunt R, Moayyedi P,

Rokkas T, Rugge M, Selgrad M, Suerbaum S, Sugano K, El-Omar EM, European Helicobacter and Microbiota Study Group and Consensus panel.

Management of Helicobacter pylori infection-the Maastricht V/Florence Consensus Report. Gut 66:6-30, 2017.

10. Ferreira RM, Pereira-Marques J, Pinto-Ribeiro I, Costa JL, Carneiro F, Machado JC, Figueiredo C. Gastric microbial community profiling reveals a

dysbiotic cancer-associated microbiota. Gut 2018 67:226-236, 2018.

Editorial Boards

Member of the Editorial Board of the journal Helicobacter
Member of the Editorial Board of the journal Microbiota in Health and Disease