Francis MÉGRAUD

Pubmed Publications List

 

 

 

Emeritus Professor at the University of Bordeaux,

Faculty of Medicine, Carreire Campus

Laboratoire de Bactériologie, 33076 Bordeaux cedex, France

Tel: +33 6 68 44 79 48

E-mail francis.megraud@u-bordeaux.fr

 

Current Position

  • Member of Team 4 of INSERM Unit 1312 BoRdeaux Institute of onCology (BRIC) 

 

Education

  • 1972 Diploma of Pharmacy, University of Bordeaux II

  • 1980 Doctor of Medicine, University of Bordeaux II

 

Post Graduate Training

  • 1977 Internship, Centre Hospitalier de Bordeaux, Certificate of Bacteriology, University of Bordeaux II

  • 1981 Training in cell biology research, Institute for Medical Research, Camden, New Jersey, USA

  • 1984 Epidemiology Intelligence Service Course, Center for Diseases Control, Atlanta, Georgia, USA

  • 1985 Training in Campylobacter research, Laboratory Centre for Diseases Control, Ottawa, Canada

  • 1985 Diploma for Study and Research in Human Biology, University René Descartes, Paris, France

  • 1986 Diploma for Authorisation to oversee research projects, University of Bordeaux II

Academic Appointments

  • 1978 - 1982   Assistant Professor of Bacteriology, University of Bordeaux II

  • 1982 - 1990   Associate Professor of Bacteriology, University of Bordeaux II

  • 1990 - 2018   Professor of Bacteriology, University of Bordeaux II, then University of Bordeaux

  • Sept 2018 - present   Emeritus Professor, University of Bordeaux

Other Appointments

  • 1993 - 2016   Scientific Director of the French National Reference Centre for Campylobacters and Helicobacters

  • 2006 - 2017   Head of the Bacteriology Department of the Bordeaux University hospital                                               

  • 2007 - 2015   Head of the INSERM Unit 853 ‘Helicobacter infection, inflammation and cancer’
                                        

Awards

  • 1998   Honour medal of the Polish Society of Gastroenterology (Bydgozcz, Poland) 

  • 2005   Doctor Honoris Causa of Wrocław University, Poland 

  •  Grants have been obtained from the World Health Organization, the Biomed I programme of the European Commission (Eurohepygast 1994-1998), the French Ministry of Foreign Affairs and a number of other institutions.

Society and Committee Memberships

  • 1987 - present   Founding member and current General Secretary of the European Helicobacter & Microbiota Study Group (EHMSG)  

  • 1990 - present   Member of the Subcommittee of the International Union of Microbiological Societies (IUMS) for the taxonomy of Epsilonproteobacteria

  • 1994 - 2001   Elected member of the European Gastro Club

  • 1994 & 2010   Member of the International Agency for Research on Cancer (IARC) committee which established the carcinogenic role of H. pylori infection               

  • 1994-2018   Corresponding Fellow of the Infectious Diseases Society of America (IDSA)                                 

  • 1997   Secretary of the International Working Party which produced Guidelines for clinical trials aiming at the eradication of Helicobacter pylori                

  • 2003 - 2007   Member of the INSERM committee for Infectious diseases (CSS1) and for cancer (CT1)                

  • 2004 - 2011   Member of the Scientific Committee of the United European Gastroenterology Federation (UEGF)              

  • 2004 - 2008   Member of the Scientific Committee of the University Victor Segalen Bordeaux 2                                 

  • 2006 - 2012   Member of the Scientific Committee of the French Institute for Health Surveillance (InVS)           

  • 2007 - 2018   Member of the ‘Conseil National des Universités’ (CNU) section 45-01

  • 2007   Member of the AFSSAPS Working Group on "Antisecretory drugs for adults"

  • 2007-2010   Member of the National Committee for the follow-up of the plan to maintain antibiotic efficacy

  • 2016 - present   Member of the Helicobacter pylori Genome Project of the National Institute for Cancer (NIC) of the NIH

  • 2018 - present   Member of the Scientific Committee of the European Registry on the Management of Helicobacter pylori infection (Hp-EuReg)

  • 2018 - present   Member of the Working Group Infections of the Committee for the Hierarchisation of Biological Acts (CHAB) of the CNAM

  • 2019 - 2020   Member of the Stool Banking Project to develop a standardised model for Faecal Microbiota Transplantation (FMT) in Europe

  • 2019 - 2021 Member of the Advisory Board for the Project "Encuesta Latino Americana de Resistencia de Helicobacter pylori a antibioticos" (HpRESLA)

  •  

  • 2020   Member of the project: Translating Faecal Microbiota Transplantation (FMT) applications related to Clostridioides difficile infection into local clinical practice in Romania

  • 2020 - present   Member of the Association of South East Asian Nations (ASEAN) Helicobacter & Microbiota Group

  • 2020 - present   Member of the Scientific Committee of the National Agency for the Security of Alimentary Products, Environment and Workplace (ANSES)

  • 2020 - present  Member of the Advisory Board for the Project "Prevention of gastric cancer: an Alliance between America and Europe" (pGAC AlliancE)

Member of the following societies:

  • American Gastroenterology Association (AGA),

  • American Society of Microbiology (ASM),

  • European Society of Clinical Microbiology and Infectious Diseases (ESCMID),

  • Société Française de Microbiologie (SFM),

  • Société Nationale Française de GastroEntérologie (SNFGE)

  • Société de Pathologie Infectieuse de Langue Française (SPILF)
     

  • Co-organization of the Maastricht conferences (I to VI) of the EHMSG on the Management of H. pylori infection

  • Participation at the following Consensus conferences:
    - Joint EPSGHAN and NASGHAN guidelines for H. pylori in children 2011, 2017 & 2022
    - EGILS (European Gastro-Intestinal Lymphoma Study group) consensus report on   MALT lymphoma 2011
    - MAPS (Management of the Precancerous conditions and lesions of the Stomach) guidelines 2012 & 2018

Research Interests

  • H. pylori diagnosis and epidemiology, selected aspects of pathogenicity, gastric cancer and susceptibility to antimicrobial agents.

 

Books published

  • Gastroduodenal pathology and Campylobacter pylori, Ed. Mégraud F., Lamouliatte H., Elsevier, Amsterdam, 1989, 659 pages.

  • Helicobacter pylori. Method for clinical diagnosis and basic research. Ed. Lee A., Mégraud F., Saunders, London, 1995, 305 pages.

  • Helicobacter pylori. Ed. Mégraud F., Lamouliatte H., Elsevier, Paris, Vol 1, 380 pages (1996). Vol 2, 500 pages (1997) in French.

    Co-editor of:

  • The Year in Helicobacter pylori (special issue of Current Opinion in Gastroenterology), Ed. Malfertheiner P., Mégraud F., Michetti P., Price A. yearly from 1994 to 2001.

  • The Year in Helicobacter, Ed. Mégraud F., Malfertheiner P. yearly from 2002 to 2022
    (special issue of the journal Helicobacter until 2020 and of Microbiota in Health and Disease since 2020)

  • Author of several chapters in different books published on Helicobacter pylori. 

 

Publications

  • PubMed: 535 publications

  • Web of Science: H index 82; 29,483 citations

  • 10 best publications on Helicobacter:
    - Mégraud F, Bonnet F, Garnier M, Lamouliatte H. Characterization of "Campylobacter pyloridis" by culture, enzymatic profile, and protein content. J Clin Microbiol. 1985;22(6):1007-10.
    - Mégraud F, Brassens-Rabbé MP, Denis F, Belbouri A, Hoa DQ. Seroepidemiology of Campylobacter pylori infection in various populations. J Clin Microbiol. 1989;27(8):1870-3.
    - Monteiro L, Bonnemaison D, Vekris A, Petry KG, Bonnet J, Vidal R, Cabrita J, Mégraud F. Complex polysaccharides as PCR inhibitors in feces: Helicobacter pylori model. J Clin Microbiol. 1997;35(4):995-8.
    - Marais A, Mendz GL, Hazell SL, Mégraud F. Metabolism and genetics of Helicobacter pylori: the genome era. Microbiol Mol Biol Rev. 1999;63(3):642-74.
    - Avenaud P1, Marais A, Monteiro L, Le Bail B, Bioulac Sage P, Balabaud C, Mégraud F. Detection of Helicobacter species in the liver of patients with and without primary liver carcinoma. Cancer. 2000;89(7):1431-9.
    - Broutet N, Tchamgoué S, Pereira E, Lamouliatte H, Salamon R, Mégraud F. Risk factors for failure of Helicobacter pylori therapy--results of an individual data analysis of 2751 patients. Aliment Pharmacol Ther. 2003;17(1):99-109.
    - Oleastro M1, Ménard A, Santos A, Lamouliatte H, Monteiro L, Barthélémy P, Mégraud F. Real-time PCR assay for rapid and accurate detection of point mutations conferring resistance to clarithromycin in Helicobacter pylori. J Clin Microbiol. 2003 ;41(1):397-402.
    - Malfertheiner P, Bazzoli F, Delchier JC, Celiñski K, Giguère M, Rivière M, Mégraud F; Pylera Study Group. Helicobacter pylori eradication with a capsule containing bismuth subcitrate potassium, metronidazole, and tetracycline given with omeprazole versus clarithromycin-based triple therapy: a randomised, open-label, non-inferiority, phase 3 trial. Lancet. 2011;377:905-13.
    - Mégraud F, Coenen S, Versporten A, Kist M, Lopez-Brea M, Hirschl AM, Andersen LP, Goossens H, Glupczynski Y; Study Group participants. Helicobacter pylori resistance to antibiotics in Europe and its relationship to antibiotic consumption. Gut. 2013;62(1):34-42.

       - Megraud F, Bruyndonckx R, Coenen S, Wittkop L, Huang TD, Hoebeke M, Bénéjat L, Lehours P, Goossens H, Glupczynski Y, European Helicobacter

       pylori Antimicrobial Susceptibility Testing Working Group. Helicobacter pylori resistance to antibiotics in Europe in 2018 and its relationship to

       antibiotic consumption in the community. Gut. 2021;70(10):1815-1822.

Editorial Boards

  • Assistant Editor of Helicobacter

  • Senior Editor of Gut Pathogens

  • Deputy Editor of Microbiota in Health and Disease

  • Member of the Editorial Board of the following journals:

      - Doctor Ru Medical Journal (Russia)

      - European Journal of Gastroenterology and Hepatology

      - European Review for Medical and Pharmacological Sciences

      - Folia Gastroenterologica Hepatologica (Czech Republic)

      - Gut and Liver (Korea)

      - Journal of Digestive Diseases (China)

      - Minerva Gastroenterologica e Diabetologica (Italy)

      - Lancet Infectious Diseases 2001 - 2003

      - Clinical Microbiology and Infection 2002 - 2018

      - World Journal of Gastroenterology 2007 - 2009

Photo FM Feb 2022 IMG_1596.JPG